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4J97

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659E Mutation Identified in Endometrial Cancer.

Summary for 4J97
Entry DOI10.2210/pdb4j97/pdb
Related2PSQ 2PVF 4J95 4J96 4J98 4J99
DescriptorFibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION, ... (4 entities in total)
Functional Keywordskinase domain fold consisting of n- and c-lobes, receptor tyrosine kinase, atp binding, transferase
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
Total number of polymer chains4
Total formula weight150943.21
Authors
Chen, H.,Mohammadi, M. (deposition date: 2013-02-15, release date: 2013-08-07, Last modification date: 2023-09-20)
Primary citationChen, H.,Huang, Z.,Dutta, K.,Blais, S.,Neubert, T.A.,Li, X.,Cowburn, D.,Traaseth, N.J.,Mohammadi, M.
Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.
Cell Rep, 4:376-384, 2013
Cited by
PubMed: 23871672
DOI: 10.1016/j.celrep.2013.06.025
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5482 Å)
Structure validation

217705

数据于2024-03-27公开中

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