4J97

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659E Mutation Identified in Endometrial Cancer.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Fibroblast growth factor receptor 2	polymer	324	37110.5	4	UniProt (P21802) Pfam (PF07714)	Homo sapiens (human)	FGFR-2, K-sam, KGFR, Keratinocyte growth factor receptor
2	E, H, J, L (A, B, C, D)	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	4	Chemie (ACP)
3	F, G, I, K, M (A, B, C, D)	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
4	N, O, P, Q (A, B, C, D)	water	water		18.0	129	Chemie (HOH)

Sequence modifications

A, B, C, D: 458 - 768 (UniProt: P21802)

PDB	External Database	Details
Met 445	-	expression tag
Gly 446	-	expression tag
Ser 447	-	expression tag
Ser 448	-	expression tag
His 449	-	expression tag
His 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
Ser 455	-	expression tag
Gln 456	-	expression tag
Asp 457	-	expression tag
Ala 491	Cys 491	engineered mutation
Glu 659	Lys 659	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	148442.1
Non-Polymers*	Number of molecules	9
	Total formula weight	2501.1
All*	Total formula weight	150943.2

*Water molecules are not included.