4J95

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome in Space Group C2.

4J95 の概要

• エントリーDOI: 10.2210/pdb4j95/pdb
• 関連するPDBエントリー: 2PSQ 2PVF 2PVY 4J96 4J97 4J98 4J99
• 分子名称: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: kinase domain fold consisting of n- and c-lobes, receptor tyrosine kinase, atp binding, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 151075.29

構造登録者

Chen, H.,Mohammadi, M. (登録日: 2013-02-15, 公開日: 2013-08-07, 最終更新日: 2023-09-20)

• 主引用文献: Chen, H.,Huang, Z.,Dutta, K.,Blais, S.,Neubert, T.A.,Li, X.,Cowburn, D.,Traaseth, N.J.,Mohammadi, M.; Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.; Cell Rep, 4:376-384, 2013; PubMed: 23871672; DOI: 10.1016/j.celrep.2013.06.025

実験手法

X-RAY DIFFRACTION (2.3767 Å)