4IXG
pcDHFR-268-K37S-N69F variant
Summary for 4IXG
Entry DOI | 10.2210/pdb4ixg/pdb |
Related | 4IXE 4IXF 4IXG |
Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N~6~-methyl-N~6~-phenylpyrido[2,3-d]pyrimidine-2,4,6-triamine, ... (4 entities in total) |
Functional Keywords | dihydrofolate reductase inhibitor ternary complex double variant, reductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Pneumocystis carinii |
Total number of polymer chains | 1 |
Total formula weight | 24855.08 |
Authors | Cody, V. (deposition date: 2013-01-25, release date: 2013-05-15, Last modification date: 2023-09-20) |
Primary citation | Gangjee, A.,Namjoshi, O.A.,Raghavan, S.,Queener, S.F.,Kisliuk, R.L.,Cody, V. Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3-d]pyrimidine Analogues As Antifolates; Application of Buchwald-Hartwig Aminations of Heterocycles. J.Med.Chem., 56:4422-4441, 2013 Cited by PubMed: 23627352DOI: 10.1021/jm400086g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
Download full validation report