4IXG
pcDHFR-268-K37S-N69F variant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| X | 0004146 | molecular_function | dihydrofolate reductase activity |
| X | 0005739 | cellular_component | mitochondrion |
| X | 0006730 | biological_process | one-carbon metabolic process |
| X | 0016491 | molecular_function | oxidoreductase activity |
| X | 0046452 | biological_process | dihydrofolate metabolic process |
| X | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| X | 0046655 | biological_process | folic acid metabolic process |
| X | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NDP X 301 |
| Chain | Residue |
| X | VAL11 |
| X | GLY58 |
| X | ARG59 |
| X | LYS60 |
| X | THR61 |
| X | SER64 |
| X | ILE80 |
| X | THR81 |
| X | ARG82 |
| X | LYS96 |
| X | ILE123 |
| X | ALA12 |
| X | GLY125 |
| X | ALA126 |
| X | GLN127 |
| X | LEU128 |
| X | TYR129 |
| X | ALA131 |
| X | IXG302 |
| X | HOH410 |
| X | HOH420 |
| X | HOH425 |
| X | ILE19 |
| X | GLY20 |
| X | ARG21 |
| X | ASN23 |
| X | SER24 |
| X | LEU25 |
| X | TRP27 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE IXG X 302 |
| Chain | Residue |
| X | ILE10 |
| X | VAL11 |
| X | ALA12 |
| X | LEU25 |
| X | GLU32 |
| X | ILE33 |
| X | PHE36 |
| X | ILE123 |
| X | TYR129 |
| X | THR144 |
| X | NDP301 |
| X | HOH434 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGrsnsLPWklkk.EisyFsrvT |
| Chain | Residue | Details |
| X | GLY18-THR40 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 198 |
| Details | Domain: {"description":"DHFR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00660","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10194348","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10736154","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12037296","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12198294","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17019704","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10194348","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
