4IXG
pcDHFR-268-K37S-N69F variant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (X) | Dihydrofolate reductase | polymer | 206 | 23843.4 | 1 | UniProt (P16184) Pfam (PF00186) | Pneumocystis carinii | |
| 2 | B (X) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 3 | C (X) | N~6~-methyl-N~6~-phenylpyrido[2,3-d]pyrimidine-2,4,6-triamine | non-polymer | 266.3 | 1 | Chemie (IXG) | |||
| 4 | D (X) | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence modifications
X: 1 - 206 (UniProt: P16184)
| PDB | External Database | Details |
|---|---|---|
| Ser 37 | Lys 37 | engineered mutation |
| Asn 69 | Phe 69 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23843.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1011.7 | |
| All* | Total formula weight | 24855.1 |
