4ITL

Crystal structure of LpxK from Aquifex aeolicus in complex with AMP-PCP at 2.1 angstrom resolution

Summary for 4ITL

Entry DOI	10.2210/pdb4itl/pdb
Related	4EHW 4EHX 4EHY
Descriptor	Tetraacyldisaccharide 4'-kinase, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, GLYCEROL, ... (4 entities in total)
Functional Keywords	membrane protein, kinase, lipid a, p-loop, p-loop containing nucleoside triphosphate hydrolase, disaccharide-1-phosphate 4'-kinase, membrane, transferase, lipid metabolism, tetraacyldisaccharide 4'-kinase
Biological source	Aquifex aeolicus
Total number of polymer chains	1
Total formula weight	37379.22
Authors	Emptage, R.P.,Pemble IV, C.W.,York, J.D.,Raetz, C.R.H.,Zhou, P. (deposition date: 2013-01-18, release date: 2013-04-03, Last modification date: 2023-09-20)
Primary citation	Emptage, R.P.,Pemble, C.W.,York, J.D.,Raetz, C.R.,Zhou, P. Mechanistic Characterization of the Tetraacyldisaccharide-1-phosphate 4'-Kinase LpxK Involved in Lipid A Biosynthesis. Biochemistry, 52:2280-2290, 2013 Cited by PubMed: 23464738 DOI: 10.1021/bi400097z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.09 Å)

Structure validation