4IMS

Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-((5-(3-aminopropyl)-1,3-phenylene)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine)

4IMS の概要

• エントリーDOI: 10.2210/pdb4ims/pdb
• 関連するPDBエントリー: 4IMT 4IMU 4IMW 4IMX
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-{[5-(3-aminopropyl)benzene-1,3-diyl]diethane-2,1-diyl}bis(4-methylpyridin-2-amine), ... (7 entities in total)
• 機能のキーワード: oxidoreductase nitric oxide synthase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Rattus norvegicus (rat)
• 細胞内の位置: Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100121.28

構造登録者

Li, H.,Poulos, T.L. (登録日: 2013-01-03, 公開日: 2013-04-24, 最終更新日: 2023-09-20)

• 主引用文献: Huang, H.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.; Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.; J.Med.Chem., 56:3024-3032, 2013; PubMed: 23451760; DOI: 10.1021/jm4000984

実験手法

X-RAY DIFFRACTION (2.15 Å)