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4IJL

Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A

Summary for 4IJL
Entry DOI10.2210/pdb4ijl/pdb
Related4IJH
DescriptorReplication protein A 70 kDa DNA-binding subunit, {[5-(3-chloro-1-benzothiophen-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid (3 entities in total)
Functional Keywordsob-fold, protein-protein interaction, dna binding protein-inhibitor complex, dna binding protein/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P27694
Total number of polymer chains1
Total formula weight14301.51
Authors
Feldkamp, M.D.,Patrone, J.D.,Kennedy, J.P.,Frank, A.O.,Vangamudi, B.,Pelz, N.F.,Rossanese, O.W.,Waterson, A.G.,Fesik, S.W.,Chazin, W.J. (deposition date: 2012-12-21, release date: 2013-08-14, Last modification date: 2023-09-20)
Primary citationPatrone, J.D.,Kennedy, J.P.,Frank, A.O.,Feldkamp, M.D.,Vangamudi, B.,Pelz, N.F.,Rossanese, O.W.,Waterson, A.G.,Chazin, W.J.,Fesik, S.W.
Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A.
ACS MED.CHEM.LETT., 4:601-605, 2013
Cited by
PubMed: 23914285
DOI: 10.1021/ml400032y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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