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4IJL

Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AReplication protein A 70 kDa DNA-binding subunitpolymer12313497.71UniProt (P27694)
Pfam (PF04057)
In PDB
Homo sapiens (human)RP-A p70, Replication factor A protein 1, RF-A protein 1, Single-stranded DNA-binding protein
2A{[5-(3-chloro-1-benzothiophen-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acidnon-polymer401.92Chemie (1EK)
3waterwater18.058Chemie (HOH)
Sequence modifications
A: 1 - 120 (UniProt: P27694)
PDBExternal DatabaseDetails
Gly -2-expression tag
Ser -1-expression tag
His 0-expression tag
Arg 7Glu 7engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight13497.7
Non-Polymers*Number of molecules2
Total formula weight803.8
All*Total formula weight14301.5
*Water molecules are not included.

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PDB entries from 2024-04-24

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