4IHL
Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A
Summary for 4IHL
Entry DOI | 10.2210/pdb4ihl/pdb |
Related | 1A4O 1IB1 1QJA 1QJB 3E6Y 3SMK 4FJ3 4IEA |
Descriptor | 14-3-3 protein zeta/delta, RAF proto-oncogene serine/threonine-protein kinase, POTASSIUM ION, ... (5 entities in total) |
Functional Keywords | 14-3-3 fold, raf, all alpha-helical, adapter protein, protein-protein interaction, peptide binding protein |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P63104 P04049 |
Total number of polymer chains | 3 |
Total formula weight | 58948.32 |
Authors | Molzan, M.,Ottmann, C. (deposition date: 2012-12-19, release date: 2013-09-25, Last modification date: 2024-10-09) |
Primary citation | Molzan, M.,Kasper, S.,Roglin, L.,Skwarczynska, M.,Sassa, T.,Inoue, T.,Breitenbuecher, F.,Ohkanda, J.,Kato, N.,Schuler, M.,Ottmann, C. Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers. Acs Chem.Biol., 8:1869-1875, 2013 Cited by PubMed: 23808890DOI: 10.1021/cb4003464 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report