4IHL

Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	14-3-3 protein zeta/delta	polymer	235	26720.2	2	UniProt (P63104) Pfam (PF00244) In PDB	Homo sapiens (human)	Protein kinase C inhibitor protein 1, KCIP-1
2	P	RAF proto-oncogene serine/threonine-protein kinase	polymer	36	4184.2	1	UniProt (P04049) In PDB	Homo sapiens	Proto-oncogene c-RAF, cRaf, Raf-1
3	A, B	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
4	A, B	(1R,3aS,4R,5R,6R,9aR,10E)-6-({(1S,2R,4S,5R,6R,8S,9S)-5-hydroxy-2-(methoxymethyl)-9-methyl-9-[(2S)-oxiran-2-yl]-3,7,10,1 1-tetraoxatricyclo[6.2.1.0~1,6~]undec-4-yl}oxy)-1-(methoxymethyl)-4,9a-dimethyl-7-(propan-2-yl)-1,2,3,3a,4,5,6,8,9,9a-de cahydrodicyclopenta[a,d][8]annulene-1,5-diol	non-polymer		622.7	2	Chemie (1F5)
5		water	water		18.0	294	Chemie (HOH)

Sequence modifications

A, B: 1 - 230 (UniProt: P63104)

PDB	External Database	Details
Gly -4	-	expression tag
Ala -3	-	expression tag
Met -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	57624.6
Non-Polymers*	Number of molecules	4
	Total formula weight	1323.7
All*	Total formula weight	58948.3

*Water molecules are not included.