4IHL
Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 14-3-3 protein zeta/delta | polymer | 235 | 26720.2 | 2 | UniProt (P63104) Pfam (PF00244) | Homo sapiens (human) | Protein kinase C inhibitor protein 1, KCIP-1 |
| 2 | C (P) | RAF proto-oncogene serine/threonine-protein kinase | polymer | 36 | 4184.2 | 1 | UniProt (P04049) | Homo sapiens | Proto-oncogene c-RAF, cRaf, Raf-1 |
| 3 | D, F (A, B) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) PubChem (813) | |||
| 4 | E, G (A, B) | (1R,3aS,4R,5R,6R,9aR,10E)-6-({(1S,2R,4S,5R,6R,8S,9S)-5-hydroxy-2-(methoxymethyl)-9-methyl-9-[(2S)-oxiran-2-yl]-3,7,10,1 1-tetraoxatricyclo[6.2.1.0~1,6~]undec-4-yl}oxy)-1-(methoxymethyl)-4,9a-dimethyl-7-(propan-2-yl)-1,2,3,3a,4,5,6,8,9,9a-de cahydrodicyclopenta[a,d][8]annulene-1,5-diol | non-polymer | 622.7 | 2 | Chemie (1F5) PubChem (176507572) PubChem (53298501) PubChem (432945) PubChem (71720906) PubChem (95907791) PubChem (5458687) PubChem (5477444) PubChem (131871712) PubChem (95907792) PubChem (10054664) PubChem (135574420) PubChem (137117224) PubChem (146034397) PubChem (162403272) PubChem (162901771) PubChem (162901772) PubChem (171346412) | |||
| 5 | H, I, J (A, B, P) | water | water | 18.0 | 294 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 230 (UniProt: P63104)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 57624.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1323.7 | |
| All* | Total formula weight | 58948.3 |
