4IHL
Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 14-3-3 protein zeta/delta | polymer | 235 | 26720.2 | 2 | UniProt (P63104) Pfam (PF00244) | Homo sapiens (human) | Protein kinase C inhibitor protein 1, KCIP-1 |
| 2 | C (P) | RAF proto-oncogene serine/threonine-protein kinase | polymer | 36 | 4184.2 | 1 | UniProt (P04049) | Homo sapiens | Proto-oncogene c-RAF, cRaf, Raf-1 |
| 3 | D, F (A, B) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 4 | E, G (A, B) | (1R,3aS,4R,5R,6R,9aR,10E)-6-({(1S,2R,4S,5R,6R,8S,9S)-5-hydroxy-2-(methoxymethyl)-9-methyl-9-[(2S)-oxiran-2-yl]-3,7,10,1 1-tetraoxatricyclo[6.2.1.0~1,6~]undec-4-yl}oxy)-1-(methoxymethyl)-4,9a-dimethyl-7-(propan-2-yl)-1,2,3,3a,4,5,6,8,9,9a-de cahydrodicyclopenta[a,d][8]annulene-1,5-diol | non-polymer | 622.7 | 2 | Chemie (1F5) | |||
| 5 | H, I, J (A, B, P) | water | water | 18.0 | 294 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 230 (UniProt: P63104)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 57624.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1323.7 | |
| All* | Total formula weight | 58948.3 |
