4I89
Crystal structure of transthyretin in complex with diflunisal at acidic pH
Summary for 4I89
Entry DOI | 10.2210/pdb4i89/pdb |
Related | 4I85 4I87 |
Descriptor | Transthyretin, 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID (3 entities in total) |
Functional Keywords | amyloidosis, fibrillogenesis inhibitor, transthyretin stabilizers, t4 or t3 hormone, plasma, transport protein-inhibitor complex, transport protein/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28002.96 |
Authors | Zanotti, G.,Cendron, L.,Folli, C.,Florio, P.,Imbimbo, B.P.,Berni, R. (deposition date: 2012-12-03, release date: 2013-06-19, Last modification date: 2023-09-20) |
Primary citation | Zanotti, G.,Cendron, L.,Folli, C.,Florio, P.,Imbimbo, B.P.,Berni, R. Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors. Febs Lett., 587:2325-2331, 2013 Cited by PubMed: 23792159DOI: 10.1016/j.febslet.2013.06.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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