4I7C

Siah1 mutant bound to synthetic peptide (ACE)KLRPV(23P)MVRPWVR

Summary for 4I7C

Entry DOI	10.2210/pdb4i7c/pdb
Related	1K2F 2A25 2AN6 4I7B 4I7D
Related PRD ID	PRD_000942
Descriptor	E3 ubiquitin-protein ligase SIAH1, Protein phyllopod, ZINC ION, ... (5 entities in total)
Functional Keywords	sina, beta sandwich, zinc finger, ubiquitin ligase, covalent inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: Q8IUQ4 Nucleus: Q27934
Total number of polymer chains	4
Total formula weight	47872.56
Authors	Santelli, E.,Stebbins, J.L.,Feng, Y.,De, S.K.,Purves, A.,Motamedchaboki, K.,Wu, B.,Ronai, Z.A.,Liddington, R.C.,Pellecchia, M. (deposition date: 2012-11-30, release date: 2013-08-14, Last modification date: 2023-12-06)
Primary citation	Stebbins, J.L.,Santelli, E.,Feng, Y.,De, S.K.,Purves, A.,Motamedchaboki, K.,Wu, B.,Ronai, Z.A.,Liddington, R.C.,Pellecchia, M. Structure-based design of covalent siah inhibitors. Chem.Biol., 20:973-982, 2013 Cited by PubMed: 23891150 DOI: 10.1016/j.chembiol.2013.06.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation