4I7C

Siah1 mutant bound to synthetic peptide (ACE)KLRPV(23P)MVRPWVR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0007275	biological_process	multicellular organism development
A	0008270	molecular_function	zinc ion binding
C	0005737	cellular_component	cytoplasm
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0007275	biological_process	multicellular organism development
C	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 601

Chain	Residue
A	CYS128
A	CYS135
A	HIS147
A	HIS152

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 602

Chain	Residue
A	CYS98
A	CYS105
A	HIS117
A	CYS121

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD A 603

Chain	Residue
A	PRO131
A	HIS152
A	SER154
A	ASP177
B	TRP123
A	CYS130

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 601

Chain	Residue
C	CYS128
C	CYS135
C	HIS147
C	HIS152

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 602

Chain	Residue
C	CYS98
C	CYS105
C	HIS117
C	CYS121

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD C 603

Chain	Residue
C	PRO131
C	HIS152
C	SER154
D	TRP123

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	ZN_FING: SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455

Chain	Residue	Details
A	SER93-LYS153
C	SER93-LYS153

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ

Chain	Residue	Details
A	CYS98
A	CYS105
A	HIS117
A	CYS121
C	CYS98
C	CYS105
C	HIS117
C	CYS121

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ

Chain	Residue	Details
A	CYS128
A	CYS135
A	HIS147
A	HIS152
C	CYS128
C	CYS135
C	HIS147
C	HIS152

---