4I72
Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with Immucillin A
Summary for 4I72
Entry DOI | 10.2210/pdb4i72/pdb |
Related | 3EPW 3FZ0 4I70 4I71 4I73 4I74 4I75 |
Descriptor | Inosine-adenosine-guanosine-nucleoside hydrolase, CALCIUM ION, 3,4-PYRROLIDINEDIOL,2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)-2S,3S,4R,5R, ... (6 entities in total) |
Functional Keywords | nucleoside hydrolase, open (alpha, beta) structure, nh fold, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Trypanosoma brucei brucei |
Total number of polymer chains | 2 |
Total formula weight | 73723.14 |
Authors | Giannese, F.,Degano, M. (deposition date: 2012-11-30, release date: 2013-08-07, Last modification date: 2013-12-18) |
Primary citation | Giannese, F.,Berg, M.,Van der Veken, P.,Castagna, V.,Tornaghi, P.,Augustyns, K.,Degano, M. Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor Acta Crystallogr.,Sect.D, 69:1553-1566, 2013 Cited by PubMed: 23897478DOI: 10.1107/S0907444913010792 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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