4I72

Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with Immucillin A

4I72 の概要

• エントリーDOI: 10.2210/pdb4i72/pdb
• 関連するPDBエントリー: 3EPW 3FZ0 4I70 4I71 4I73 4I74 4I75
• 分子名称: Inosine-adenosine-guanosine-nucleoside hydrolase, CALCIUM ION, 3,4-PYRROLIDINEDIOL,2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)-2S,3S,4R,5R, ... (6 entities in total)
• 機能のキーワード: nucleoside hydrolase, open (alpha, beta) structure, nh fold, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Trypanosoma brucei brucei
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73723.14

構造登録者

Giannese, F.,Degano, M. (登録日: 2012-11-30, 公開日: 2013-08-07, 最終更新日: 2013-12-18)

• 主引用文献: Giannese, F.,Berg, M.,Van der Veken, P.,Castagna, V.,Tornaghi, P.,Augustyns, K.,Degano, M.; Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor; Acta Crystallogr.,Sect.D, 69:1553-1566, 2013; PubMed: 23897478; DOI: 10.1107/S0907444913010792

実験手法

X-RAY DIFFRACTION (2.05 Å)