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4I71

Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with a trypanocidal compound

Summary for 4I71
Entry DOI10.2210/pdb4i71/pdb
Related3EPW 3FZ0 4I70 4I72 4I73 4I74 4I75
DescriptorInosine-adenosine-guanosine-nucleoside hydrolase, (2R,3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidine-3,4-diol, CALCIUM ION, ... (6 entities in total)
Functional Keywordsnucleoside hydrolase, open (alpha, beta) structure, nh fold, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceTrypanosoma brucei brucei
Total number of polymer chains1
Total formula weight36843.87
Authors
Giannese, F.,Degano, M. (deposition date: 2012-11-30, release date: 2013-08-07, Last modification date: 2023-11-08)
Primary citationGiannese, F.,Berg, M.,Van der Veken, P.,Castagna, V.,Tornaghi, P.,Augustyns, K.,Degano, M.
Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor
Acta Crystallogr.,Sect.D, 69:1553-1566, 2013
Cited by
PubMed: 23897478
DOI: 10.1107/S0907444913010792
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.28 Å)
Structure validation

221051

數據於2024-06-12公開中

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