4I71
Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with a trypanocidal compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Inosine-adenosine-guanosine-nucleoside hydrolase | polymer | 330 | 36167.6 | 1 | UniProt (Q57ZL6) Pfam (PF01156) | Trypanosoma brucei brucei | |
| 2 | B (A) | (2R,3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidine-3,4-diol | non-polymer | 279.3 | 1 | Chemie (AGV) | |||
| 3 | C (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | D, E, G, H (A) | NICKEL (II) ION | non-polymer | 58.7 | 4 | Chemie (NI) | |||
| 5 | F (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 6 | I (A) | water | water | 18.0 | 282 | Chemie (HOH) |
Sequence modifications
A: 1 - 327 (UniProt: Q57ZL6)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36167.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 676.3 | |
| All* | Total formula weight | 36843.9 |
