4I71

Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with a trypanocidal compound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0008477	molecular_function	purine nucleosidase activity
A	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0020015	cellular_component	glycosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE AGV A 401

Chain	Residue
A	ASN12
A	ASN186
A	GLU248
A	ARG252
A	TYR257
A	TRP260
A	ASP261
A	CA402
A	HOH504
A	HOH535
A	HOH559
A	ASP14
A	ASP15
A	ASP40
A	PHE79
A	TRP83
A	THR137
A	ASN173
A	GLU184

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 402

Chain	Residue
A	ASP10
A	ASP15
A	THR137
A	ASP261
A	AGV401
A	HOH504

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NI A 403

Chain	Residue
A	HIS58
A	ASP253
A	TRS405
A	HOH501

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NI A 404

Chain	Residue
A	GLY-2
A	SER-1
A	HIS0

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site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TRS A 405

Chain	Residue
A	HIS58
A	LEU65
A	LEU104
A	LYS107
A	ILE250
A	LEU251
A	ASP253
A	NI403
A	HOH501
A	HOH586
A	HOH687
A	HOH773

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NI A 406

Chain	Residue
A	HIS115

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site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NI A 407

Chain	Residue
A	HIS317
A	HOH656
A	HOH701

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