4I71
Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with a trypanocidal compound
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005829 | cellular_component | cytosol |
A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
A | 0006152 | biological_process | purine nucleoside catabolic process |
A | 0006166 | biological_process | purine ribonucleoside salvage |
A | 0008477 | molecular_function | purine nucleosidase activity |
A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
A | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
A | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
A | 0020015 | cellular_component | glycosome |
A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE AGV A 401 |
Chain | Residue |
A | ASN12 |
A | ASN186 |
A | GLU248 |
A | ARG252 |
A | TYR257 |
A | TRP260 |
A | ASP261 |
A | CA402 |
A | HOH504 |
A | HOH535 |
A | HOH559 |
A | ASP14 |
A | ASP15 |
A | ASP40 |
A | PHE79 |
A | TRP83 |
A | THR137 |
A | ASN173 |
A | GLU184 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 402 |
Chain | Residue |
A | ASP10 |
A | ASP15 |
A | THR137 |
A | ASP261 |
A | AGV401 |
A | HOH504 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NI A 403 |
Chain | Residue |
A | HIS58 |
A | ASP253 |
A | TRS405 |
A | HOH501 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NI A 404 |
Chain | Residue |
A | GLY-2 |
A | SER-1 |
A | HIS0 |
site_id | AC5 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE TRS A 405 |
Chain | Residue |
A | HIS58 |
A | LEU65 |
A | LEU104 |
A | LYS107 |
A | ILE250 |
A | LEU251 |
A | ASP253 |
A | NI403 |
A | HOH501 |
A | HOH586 |
A | HOH687 |
A | HOH773 |
site_id | AC6 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE NI A 406 |
Chain | Residue |
A | HIS115 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NI A 407 |
Chain | Residue |
A | HIS317 |
A | HOH656 |
A | HOH701 |