4I71

Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with a trypanocidal compound

4I71 の概要

• エントリーDOI: 10.2210/pdb4i71/pdb
• 関連するPDBエントリー: 3EPW 3FZ0 4I70 4I72 4I73 4I74 4I75
• 分子名称: Inosine-adenosine-guanosine-nucleoside hydrolase, (2R,3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidine-3,4-diol, CALCIUM ION, ... (6 entities in total)
• 機能のキーワード: nucleoside hydrolase, open (alpha, beta) structure, nh fold, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Trypanosoma brucei brucei
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36843.87

構造登録者

Giannese, F.,Degano, M. (登録日: 2012-11-30, 公開日: 2013-08-07, 最終更新日: 2023-11-08)

• 主引用文献: Giannese, F.,Berg, M.,Van der Veken, P.,Castagna, V.,Tornaghi, P.,Augustyns, K.,Degano, M.; Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor; Acta Crystallogr.,Sect.D, 69:1553-1566, 2013; PubMed: 23897478; DOI: 10.1107/S0907444913010792

実験手法

X-RAY DIFFRACTION (1.28 Å)