4I5B

Structure of human MHC class II protein HLA-DR1 carrying an influenza hemagglutinin peptide partially filling the binding groove

Summary for 4I5B

• Entry DOI: 10.2210/pdb4i5b/pdb
• Descriptor: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, truncated hemagglutinin peptide, ... (4 entities in total)
• Functional Keywords: immunoglobulin fold, antigen presentation, peptide-mhc complex, membrane, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P01903 P04229
• Total number of polymer chains: 6
• Total formula weight: 90792.16

Authors

Schulze, M.-S.E.D. (deposition date: 2012-11-28, release date: 2013-12-04, Last modification date: 2015-04-15)

• Primary citation: Schulze, M.S.,Anders, A.K.,Sethi, D.K.,Call, M.J.; Disruption of hydrogen bonds between major histocompatibility complex class II and the peptide N-terminus is not sufficient to form a human leukocyte antigen-DM receptive state of major histocompatibility complex class II.; Plos One, 8:e69228-e69228, 2013; PubMed: 23976922; DOI: 10.1371/journal.pone.0069228

Experimental method

X-RAY DIFFRACTION (2.12 Å)