4I2X

Crystal structure of Signal Regulatory Protein gamma (SIRP-gamma) in complex with FabOX117

Summary for 4I2X

• Entry DOI: 10.2210/pdb4i2x/pdb
• Descriptor: FabOX117 light chain, FabOX117 heavy chain, Signal-regulatory protein gamma, ... (7 entities in total)
• Functional Keywords: protein-fab complex, structural genomics, oxford protein production facility, oppf, signal regulatory protein, cd47, cell surface, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 170595.01

Authors

Nettleship, J.E.,Ren, J.,Stuart, D.I.,Owens, R.J.,Oxford Protein Production Facility (OPPF) (deposition date: 2012-11-23, release date: 2013-12-18, Last modification date: 2024-11-20)

Primary citation

Nettleship, J.E.,Ren, J.,Scott, D.J.,Rahman, N.,Hatherley, D.,Zhao, Y.,Stuart, D.I.,Barclay, A.N.,Owens, R.J.
Crystal structure of signal regulatory protein gamma (SIRP gamma) in complex with an antibody Fab fragment.
Bmc Struct.Biol., 13:13-13, 2013

PubMed Abstract: Signal Regulatory Protein γ (SIRPγ) is a member of a closely related family of three cell surface receptors implicated in modulating immune/inflammatory responses. SIRPγ is expressed on T lymphocytes where it appears to be involved in the integrin-independent adhesion of lymphocytes to antigen-presenting cells. Here we describe the first full length structure of the extracellular region of human SIRPγ.

PubMed: 23826770
DOI: 10.1186/1472-6807-13-13

Experimental method

X-RAY DIFFRACTION (2.48 Å)