4I2X

Crystal structure of Signal Regulatory Protein gamma (SIRP-gamma) in complex with FabOX117

Summary for 4I2X

DescriptorFabOX117 light chain, FabOX117 heavy chain, Signal-regulatory protein gamma, ... (7 entities in total)
Functional Keywordsprotein-fab complex, structural genomics, oxford protein production facility, oppf, signal regulatory protein, cd47, cell surface, immune system
Biological sourceHomo sapiens (human)
Cellular locationMembrane ; Single-pass type I membrane protein  Q9P1W8
Total number of polymer chains6
Total molecular weight170595.02
Authors
Nettleship, J.E.,Ren, J.,Stuart, D.I.,Owens, R.J.,Oxford Protein Production Facility (OPPF) (deposition date: 2012-11-23, release date: 2013-12-18, Last modification date: 2014-12-24)
Primary citation
Nettleship, J.E.,Ren, J.,Scott, D.J.,Rahman, N.,Hatherley, D.,Zhao, Y.,Stuart, D.I.,Barclay, A.N.,Owens, R.J.
Crystal structure of signal regulatory protein gamma (SIRP gamma) in complex with an antibody Fab fragment.
Bmc Struct.Biol., 13:13-13, 2013
PubMed: 23826770 (PDB entries with the same primary citation)
DOI: 10.1186/1472-6807-13-13
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.48 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26150.6%3.9%4.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 4i2x
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Molmil generated image of 4i2x
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Molmil generated image of 4i2x
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4i2x.pdb2.gz [245.99 KB])
Coordinate files for Biological unit (4i2x.pdb1.gz [254.94 KB])