4I2X

Crystal structure of Signal Regulatory Protein gamma (SIRP-gamma) in complex with FabOX117

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	FabOX117 light chain	polymer	214	23660.1	2		Homo sapiens (human)
2	B, D	FabOX117 heavy chain	polymer	229	24772.8	2		Homo sapiens (human)
3	E, F	Signal-regulatory protein gamma	polymer	328	36575.3	2	UniProt (Q9P1W8) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (human)	SIRP-gamma, CD172 antigen-like family member B, Signal-regulatory protein beta-2, SIRP-b2, SIRP-beta-2
4	B	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	D, E	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
6	E, F	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
7		water	water		18.0	302	Chemie (HOH)

Sequence modifications

E, F: 1 - 319 (UniProt: Q9P1W8)

PDB	External Database	Details
Ser 320	-	expression tag
Thr 321	-	expression tag
Arg 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	170016.3
Non-Polymers*	Number of molecules	5
	Total formula weight	578.7
All*	Total formula weight	170595.0

*Water molecules are not included.