4HWB

Crystal structure of ectodomain 3 of the IL-13 receptor alpha 1 in complex with a human neutralizing monoclonal antibody fragment

Summary for 4HWB

• Entry DOI: 10.2210/pdb4hwb/pdb
• Related: 4HWE
• Descriptor: Interleukin-13 receptor subunit alpha-1, Fab heavy chain, Fab light chain, ... (6 entities in total)
• Functional Keywords: fab, fniii, cytokine signaling, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P78552
• Total number of polymer chains: 3
• Total formula weight: 64410.50

Authors

Xu, Y. (deposition date: 2012-11-07, release date: 2013-02-27, Last modification date: 2013-07-24)

• Primary citation: Redpath, N.T.,Xu, Y.,Wilson, N.J.,Fabri, L.J.,Baca, M.,Andrews, A.E.,Braley, H.,Lu, P.,Ireland, C.,Ernst, R.E.,Woods, A.,Forrest, G.,An, Z.,Zaller, D.M.,Strohl, W.R.,Luo, C.S.,Czabotar, P.E.,Garrett, T.P.,Hilton, D.J.,Nash, A.D.,Zhang, J.G.,Nicola, N.A.; Crystal structure of ectodomain 3 of the IL-13 receptor alpha 1 in complex with a human neutralizing monoclonal antibody fragment; Biochem.J., 451:165-175, 2013; PubMed: 23384096; DOI: 10.1042/BJ20121819

Experimental method

X-RAY DIFFRACTION (2.61 Å)