4HWB

Crystal structure of ectodomain 3 of the IL-13 receptor alpha 1 in complex with a human neutralizing monoclonal antibody fragment

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 401

Chain	Residue
A	LYS289
A	HOH503
A	HOH506
L	SER30

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 402

Chain	Residue
A	ARG285
A	TRP304

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NHE A 403

Chain	Residue
A	TRP301
A	SER302
A	ASN303
A	NHE404
H	TYR58
A	PHE227
A	ARG230
A	ILE286

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE NHE A 404

Chain	Residue
A	ASP203
A	PRO205
A	ASN223
A	PRO224
A	ASN226
A	PHE227
A	TYR234
A	ILE286
A	NHE403
H	ASP56

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NHE A 405

Chain	Residue
A	LEU232
A	PHE233
A	TYR234
A	GLN252
A	GLU253
A	ALA254
A	LYS255

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 H 301

Chain	Residue
H	LYS20
H	GLN83

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 H 302

Chain	Residue
H	SER8
H	GLY9
H	LYS14
H	SER121
H	THR122

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 H 303

Chain	Residue
H	GLU17
H	SER18

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 H 304

Chain	Residue
H	ASN205
H	LYS207
H	LYS212
H	HOH429

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 H 305

Chain	Residue
H	VAL3
H	TYR33
H	ARG99

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NHE H 306

Chain	Residue
A	LEU293
A	TYR295
A	GLU296
A	ASP297
H	ARG60
H	TYR61
L	GLU93

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NHE H 307

Chain	Residue
A	GLU296
H	TYR58
H	THR59
H	ARG60
H	TYR61
H	GLN66

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 L 301

Chain	Residue
L	LYS40
L	GLN43
L	ARG46
L	SO4304

---

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 L 302

Chain	Residue
L	ARG208

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 L 303

Chain	Residue
L	PRO8
L	GLY9
L	THR10
L	HOH414

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 L 304

Chain	Residue
L	ARG46
L	ARG62
L	SO4301

---

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 L 305

Chain	Residue
L	ARG55
L	SER64

---

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 L 306

Chain	Residue
L	PRO60
L	ASP61
L	ARG62

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR200-HIS206
L	TYR189-HIS195

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---