4HWB
Crystal structure of ectodomain 3 of the IL-13 receptor alpha 1 in complex with a human neutralizing monoclonal antibody fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Interleukin-13 receptor subunit alpha-1 | polymer | 122 | 14650.2 | 1 | UniProt (P78552) | Homo sapiens (human) | IL-13 receptor subunit alpha-1, IL-13R subunit alpha-1, IL-13R-alpha-1, IL-13RA1, Cancer/testis antigen 19, CT19 |
| 2 | B (H) | Fab heavy chain | polymer | 227 | 24342.4 | 1 | Homo sapiens | ||
| 3 | C (L) | Fab light chain | polymer | 212 | 23132.6 | 1 | Homo sapiens | ||
| 4 | D, E, I, J, K... (A, H, L) | SULFATE ION | non-polymer | 96.1 | 13 | Chemie (SO4) | |||
| 5 | F, G, H, N, O (A, H) | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID | non-polymer | 207.3 | 5 | Chemie (NHE) | |||
| 6 | V, W, X (A, H, L) | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A: 197 - 310 (UniProt: P78552)
| PDB | External Database | Details |
|---|---|---|
| His 311 | - | expression tag |
| His 312 | - | expression tag |
| His 313 | - | expression tag |
| His 314 | - | expression tag |
| His 315 | - | expression tag |
| His 316 | - | expression tag |
| His 317 | - | expression tag |
| His 318 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 62125.2 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2285.3 | |
| All* | Total formula weight | 64410.5 |
