4HT1

Human TWEAK in complex with the Fab fragment of a neutralizing antibody

Summary for 4HT1

Entry DOI	10.2210/pdb4ht1/pdb
Descriptor	Tumor necrosis factor ligand superfamily member 12, chimeric antibody Fab, ... (4 entities in total)
Functional Keywords	antibody fab, tnf homology domain, cytokine, tweak receptor, membrane bound, extracellular thd domain, immune system
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane ; Single-pass type II membrane protein . Tumor necrosis factor ligand superfamily member 12, secreted form: Secreted. Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein: O43508
Total number of polymer chains	3
Total formula weight	64801.81
Authors	Lammens, A. (deposition date: 2012-10-31, release date: 2013-06-12, Last modification date: 2017-11-15)
Primary citation	Lammens, A.,Baehner, M.,Kohnert, U.,Niewoehner, J.,von Proff, L.,Schraeml, M.,Lammens, K.,Hopfner, K.P. Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding. Plos One, 8:e62697-e62697, 2013 Cited by PubMed: 23667509 DOI: 10.1371/journal.pone.0062697 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.498 Å)

Structure validation