Crystal structure of Tankyrase 2 in complex with 3',4'-Dihydroxyflavone

Summary for 4HLM

Related3U9H 3U9Y 3UA9 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HMH
DescriptorTankyrase-2, ZINC ION, SULFATE ION, ... (7 entities in total)
Functional Keywordsprotein-ligand complex, diphtheria toxin like fold, transferase, adp-ribosylation
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q9H2K2 Q9H2K2
Total number of polymer chains4
Total molecular weight55751.16
Narwal, M.,Haikarainen, T.,Lehtio, L. (deposition date: 2012-10-17, release date: 2012-10-31, Last modification date: 2013-05-22)
Primary citation
Narwal, M.,Haikarainen, T.,Fallarero, A.,Vuorela, P.M.,Lehtio, L.
Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56:3507-3517, 2013
PubMed: 23574272 (PDB entries with the same primary citation)
DOI: 10.1021/jm3018783
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.214200.8%6.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload