Crystal structure of human tankyrase 2 in complex with a selective inhibitor

Summary for 3UA9

Related3U9H 3U9Y
DescriptorTankyrase-2, ZINC ION, SULFATE ION, ... (6 entities in total)
Functional Keywordsprotein-ligand complex, diphtheria toxin like fold, adp-ribosylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q9H2K2
Total number of polymer chains2
Total molecular weight56145.71
Narwal, M.,Lehtio, L. (deposition date: 2011-10-21, release date: 2012-01-25, Last modification date: 2012-02-22)
Primary citation
Narwal, M.,Venkannagari, H.,Lehtio, L.
Structural basis of selective inhibition of human tankyrases.
J.Med.Chem., 55:1360-1367, 2012
PubMed: 22233320 (PDB entries with the same primary citation)
DOI: 10.1021/jm201510p
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.234202.6%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report