3UA9
Crystal structure of human tankyrase 2 in complex with a selective inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tankyrase-2 | polymer | 240 | 27299.8 | 2 | UniProt (Q9H2K2) Pfam (PF00644) | Homo sapiens (human) | TANK2, Poly [ADP-ribose] polymerase 5B, TNKS-2, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, Tankyrase II, Tankyrase-like protein, Tankyrase-related protein |
| 2 | C, H (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, E, I, J (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | F, K (A, B) | 4-[(3aR,4S,7R,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(quinolin-8-yl)benzamide | non-polymer | 409.4 | 2 | Chemie (IWR) PubChem (25093485) PubChem (44483163) PubChem (58295074) PubChem (66696053) PubChem (68315684) PubChem (70685330) PubChem (1163034) PubChem (3137736) PubChem (89960377) PubChem (91885421) PubChem (6551393) PubChem (98116186) PubChem (124920586) PubChem (139436591) PubChem (162474810) | |||
| 5 | G, L (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) PubChem (8117) | |||
| 6 | M, N (A, B) | water | water | 18.0 | 86 | Chemie (HOH) |
Sequence modifications
A, B: 946 - 1162 (UniProt: Q9H2K2)
| PDB | External Database | Details |
|---|---|---|
| Met 923 | - | expression tag |
| His 924 | - | expression tag |
| His 925 | - | expression tag |
| His 926 | - | expression tag |
| His 927 | - | expression tag |
| His 928 | - | expression tag |
| His 929 | - | expression tag |
| Ser 930 | - | expression tag |
| Ser 931 | - | expression tag |
| Gly 932 | - | expression tag |
| Val 933 | - | expression tag |
| Asp 934 | - | expression tag |
| Leu 935 | - | expression tag |
| Gly 936 | - | expression tag |
| Thr 937 | - | expression tag |
| Glu 938 | - | expression tag |
| Asn 939 | - | expression tag |
| Leu 940 | - | expression tag |
| Tyr 941 | - | expression tag |
| Phe 942 | - | expression tag |
| Gln 943 | - | expression tag |
| Ser 944 | - | expression tag |
| Met 945 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54599.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1546.2 | |
| All* | Total formula weight | 56145.7 |
