4HJJ

Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule

Summary for 4HJJ

• Entry DOI: 10.2210/pdb4hjj/pdb
• Related: 2VXV
• Descriptor: Interleukin-18, Anti-IL12 Anti-IL18 DFab Heavy Chain, Anti-IL12 Anti-IL18 DFab Light Chain, ... (7 entities in total)
• Functional Keywords: dfab complex, il-18, dual variable domain immunoglobulin, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: Q14116
• Total number of polymer chains: 3
• Total formula weight: 91905.16

Authors

Jakob, C.G.,Edalji, R.,Judge, R.A.,DiGiammarino, E.,Li, Y.,Gu, J.,Ghayur, T. (deposition date: 2012-10-12, release date: 2013-05-08)

• Primary citation: Jakob, C.G.,Edalji, R.,Judge, R.A.,Digiammarino, E.,Li, Y.,Gu, J.,Ghayur, T.; Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig[TM]) molecule; MAbs, 5:358-363, 2013; PubMed: 23549062; DOI: 10.4161/mabs.23977

Experimental method

X-RAY DIFFRACTION (2.1 Å)