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4HHF

Crystal Structure of chemically synthesized scorpion alpha-toxin OD1

Summary for 4HHF
Entry DOI10.2210/pdb4hhf/pdb
DescriptorAlpha-toxin OD1, (4S)-2-METHYL-2,4-PENTANEDIOL (3 entities in total)
Functional Keywordsscorpion long-chain alpha-toxin, gating modulator, voltage-gated sodium channels 1.4, 1.6, 1.7, inhibition of fast channel inactivation, c-terminally amidated, venom gland, toxin
Biological sourceOdontobuthus doriae (Yellow Iranian scorpion)
Cellular locationSecreted: P84646
Total number of polymer chains1
Total formula weight7575.71
Authors
Wang, C.I.A.,Lewis, R.J.,Alewood, P.F.,Durek, T. (deposition date: 2012-10-09, release date: 2013-04-24, Last modification date: 2023-09-20)
Primary citationDurek, T.,Vetter, I.,Wang, C.I.,Motin, L.,Knapp, O.,Adams, D.J.,Lewis, R.J.,Alewood, P.F.
Chemical engineering and structural and pharmacological characterization of the alpha-scorpion toxin OD1.
Acs Chem.Biol., 8:1215-1222, 2013
Cited by
PubMed: 23527544
DOI: 10.1021/cb400012k
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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