4H8E

Structure of S. aureus undecaprenyl diphosphate synthase in complex with FPP and sulfate

Summary for 4H8E

Entry DOI	10.2210/pdb4h8e/pdb
Related	4H2J 4H2M 4H2O 4H38 4H3A 4H3C
Descriptor	Undecaprenyl pyrophosphate synthase, MAGNESIUM ION, FARNESYL DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	alpha-helix, prenyl transferase, cell wall biosynthesis, farnesyl diphosphate binding, isopentenyl diphosphate binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Staphylococcus aureus subsp. aureus
Total number of polymer chains	1
Total formula weight	30404.89
Authors	Zhu, W.,Oldfield, E. (deposition date: 2012-09-22, release date: 2012-12-19, Last modification date: 2024-02-28)
Primary citation	Zhu, W.,Zhang, Y.,Sinko, W.,Hensler, M.E.,Olson, J.,Molohon, K.J.,Lindert, S.,Cao, R.,Li, K.,Wang, K.,Wang, Y.,Liu, Y.L.,Sankovsky, A.,de Oliveira, C.A.,Mitchell, D.A.,Nizet, V.,McCammon, J.A.,Oldfield, E. Antibacterial drug leads targeting isoprenoid biosynthesis. Proc.Natl.Acad.Sci.USA, 110:123-128, 2013 Cited by PubMed: 23248302 DOI: 10.1073/pnas.1219899110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation