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4H49

Crystal structure of the catalytic domain of MMP-12 in complex with a twin inhibitor.

Summary for 4H49
Entry DOI10.2210/pdb4h49/pdb
Related3LIR 4EFS 4H1Q 4H2E 4H30
DescriptorMacrophage metalloelastase, ZINC ION, CALCIUM ION, ... (9 entities in total)
Functional Keywordsdivalent inhibitor, carboxylic twin inhibitor, dimerisation, metzincin, zinc protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space, extracellular matrix : P39900
Total number of polymer chains4
Total formula weight74039.92
Authors
Antoni, C.,Stura, E.A.,Vera, L.,Nuti, E.,Carafa, L.,Cassar-Lajeunesse, E.,Dive, V.,Rossello, A. (deposition date: 2012-09-17, release date: 2013-04-24, Last modification date: 2023-09-20)
Primary citationAntoni, C.,Vera, L.,Devel, L.,Catalani, M.P.,Czarny, B.,Cassar-Lajeunesse, E.,Nuti, E.,Rossello, A.,Dive, V.,Stura, E.A.
Crystallization of bi-functional ligand protein complexes.
J.Struct.Biol., 182:246-254, 2013
Cited by
PubMed: 23567804
DOI: 10.1016/j.jsb.2013.03.015
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.16 Å)
Structure validation

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