4H1Y

Human ecto-5'-nucleotidase (CD73): crystal form II (open) in complex with PSB11552

4H1Y の概要

• エントリーDOI: 10.2210/pdb4h1y/pdb
• 関連するPDBエントリー: 4H2B 4h2f 4h2g 4h2i
• 分子名称: 5'-nucleotidase, ZINC ION, 2,2'-[(2-{[2-({[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]carbonyl}amino)ethyl]amino}-2-oxoethyl)imino]diacetic acid (non-preferred name), ... (7 entities in total)
• 機能のキーワード: dimeric, nucleotidase, hydrolase, amp binding, zinc binding, extracellular
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Lipid-anchor, GPI-anchor: P21589
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61236.17

構造登録者

Pippel, J.,Zebisch, M.,Knapp, K.,Straeter, N. (登録日: 2012-09-11, 公開日: 2012-11-28, 最終更新日: 2017-11-15)

• 主引用文献: Knapp, K.,Zebisch, M.,Pippel, J.,El-Tayeb, A.,Muller, C.E.,Strater, N.; Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling.; Structure, 20:2161-2173, 2012; PubMed: 23142347; DOI: 10.1016/j.str.2012.10.001

実験手法

X-RAY DIFFRACTION (1.58 Å)