4GYY

Crystal structure of human O-GlcNAc Transferase with UDP-5SGlcNAc and a peptide substrate

4GYY の概要

• エントリーDOI: 10.2210/pdb4gyy/pdb
• 関連するPDBエントリー: 4GYW 4GZ3 4GZ5 4GZ6
• 分子名称: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, ... (5 entities in total)
• 機能のキーワード: ogt, o-glcnac, gt-b, glycosyltransferase, glcnacylation, transferase-peptide complex, transferase/peptide
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform 2: Mitochondrion. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm: O15294
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 166281.17

構造登録者

Lazarus, M.B.,Jiang, J.,Gloster, T.M.,Zandberg, W.F.,Vocadlo, D.J.,Walker, S. (登録日: 2012-09-05, 公開日: 2012-10-31, 最終更新日: 2024-02-28)

• 主引用文献: Lazarus, M.B.,Jiang, J.,Gloster, T.M.,Zandberg, W.F.,Whitworth, G.E.,Vocadlo, D.J.,Walker, S.; Structural snapshots of the reaction coordinate for O-GlcNAc transferase.; Nat.Chem.Biol., 8:966-968, 2012; PubMed: 23103939; DOI: 10.1038/nchembio.1109

実験手法

X-RAY DIFFRACTION (1.85 Å)