4GYY

Crystal structure of human O-GlcNAc Transferase with UDP-5SGlcNAc and a peptide substrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006493	biological_process	protein O-linked glycosylation
A	0016757	molecular_function	glycosyltransferase activity
C	0006493	biological_process	protein O-linked glycosylation
C	0016757	molecular_function	glycosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	32
Details	BINDING SITE FOR RESIDUE 12V A 1501

Chain	Residue
A	HIS498
A	TYR841
A	LYS842
A	LEU866
A	VAL895
A	ALA896
A	LYS898
A	HIS901
A	ARG904
A	CYS917
A	HIS920
A	PRO559
A	THR921
A	THR922
A	ASP925
A	HOH1604
A	HOH1627
A	HOH1717
A	HOH1765
A	HOH1786
B	THR18
B	PRO19
A	THR560
B	VAL20
B	SER21
B	HOH201
A	LEU563
A	LEU653
A	GLY654
A	PRO656
A	PHE694
A	GLN839

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1502

Chain	Residue
A	GLY365
A	LEU367
A	GLN368
A	HOH1769
A	HOH1977

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 101

Chain	Residue
A	LYS634
A	GLY635
A	HOH1798
B	ASN24
B	MET25

---

site_id	AC4
Number of Residues	32
Details	BINDING SITE FOR RESIDUE 12V C 1501

Chain	Residue
C	HIS498
C	PRO559
C	THR560
C	LEU563
C	LEU653
C	GLY654
C	PRO656
C	PHE694
C	GLN839
C	TYR841
C	LYS842
C	LEU866
C	VAL895
C	ALA896
C	LYS898
C	HIS901
C	ARG904
C	CYS917
C	HIS920
C	THR921
C	THR922
C	ASP925
C	HOH1602
C	HOH1720
C	HOH1789
C	HOH1835
D	THR18
D	PRO19
D	VAL20
D	SER21
D	HOH201
D	HOH203

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 101

Chain	Residue
C	GLY635
C	HOH1861
D	ASN24
D	MET25

---

site_id	AC6
Number of Residues	26
Details	BINDING SITE FOR CHAIN B OF CASEIN KINASE II SUBUNIT ALPHA

Chain	Residue
B	HOH201
B	HOH202
B	HOH203
B	HOH204
B	HOH208
A	LEU371
A	LYS375
A	LEU395
A	ASP400
A	ASP431
A	SER494
A	HIS496
A	HIS517
A	ASN557
A	HIS558
A	PRO559
A	TYR632
A	THR633
A	LYS634
A	GLN839
A	VAL895
A	12V1501
A	HOH1620
A	HOH1627
B	TYR13
B	SO4101

---

site_id	AC7
Number of Residues	29
Details	BINDING SITE FOR CHAIN D OF CASEIN KINASE II SUBUNIT ALPHA

Chain	Residue
C	LEU371
C	LYS375
C	LEU395
C	ASP400
C	ASP431
C	SER494
C	HIS496
C	HIS517
C	ASN557
C	HIS558
C	PRO559
C	TYR632
C	THR633
C	LYS634
C	GLN839
C	VAL895
C	12V1501
D	TYR13
D	SO4101
D	HOH201
D	HOH202
D	HOH203
D	HOH204
D	HOH205
D	HOH206
D	HOH207
D	HOH208
D	HOH212
D	HOH213

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:7592773

Chain	Residue	Details
B	THR18
D	THR18

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:23103939, ECO:0007744|PDB:4GYW

Chain	Residue	Details
A	GLN839
C	HIS901
C	HIS920
C	ASP925
A	LYS842
A	ALA896
A	HIS901
A	HIS920
A	ASP925
C	GLN839
C	LYS842
C	ALA896

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by AMPK => ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:37541260

Chain	Residue	Details
A	THR444
C	THR444

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P56558

Chain	Residue	Details
A	TYR979
C	TYR979

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) serine; by autocatalysis => ECO:0000269|PubMed:27713473

Chain	Residue	Details
A	SER389
C	SER389

---