4GYY

Crystal structure of human O-GlcNAc Transferase with UDP-5SGlcNAc and a peptide substrate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit	polymer	723	80974.5	2	UniProt (O15294) Pfam (PF13424) Pfam (PF13414) Pfam (PF13844) In PDB	Homo sapiens (human)	O-GlcNAc transferase subunit p110, O-linked N-acetylglucosamine transferase 110 kDa subunit, OGT
2	B, D	Casein kinase II subunit alpha	polymer	14	1398.6	2	UniProt (P68400) In PDB	Homo sapiens	CK II alpha
3	A, C	(2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate	non-polymer		623.4	2	Chemie (12V)
4	A, B, D	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
5		water	water		18.0	836	Chemie (HOH)

Sequence modifications

A, C: 313 - 1031 (UniProt: O15294)

PDB	External Database	Details
Gly 309	-	expression tag
Pro 310	-	expression tag
Gly 311	-	expression tag
Ser 312	-	expression tag

B, D: 14 - 26 (UniProt: P68400)

PDB	External Database	Details
Tyr 13	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	164746.1
Non-Polymers*	Number of molecules	5
	Total formula weight	1535.0
All*	Total formula weight	166281.2

*Water molecules are not included.