4GUY

Human MMP12 catalytic domain in complex with*N*-Hydroxy-2-(2-(4-methoxyphenyl)ethylsulfonamido)acetamide

Replaces:  3RTU

Summary for 4GUY

• Entry DOI: 10.2210/pdb4guy/pdb
• Related: 3F15 3F16 3F17 3F1A 3LK8 3NX7
• Descriptor: Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: mmp-12, matrix, metalloproteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space, extracellular matrix : P39900
• Total number of polymer chains: 1
• Total formula weight: 18023.85

Authors

Calderone, V.,Fragai, M.,Luchinat, C.,Massaro, A.,Mordini, A.,Mori, M. (deposition date: 2012-08-30, release date: 2012-09-19, Last modification date: 2023-11-08)

• Primary citation: Mori, M.,Massaro, A.,Calderone, V.,Fragai, M.,Luchinat, C.,Mordini, A.; Contribution of free energy of solvation to ligand affinity in new potent MMPs inhibitors.; To be Published,

Experimental method