3LK8

Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor paramethoxy-sulfonyl-glycine hydroxamate

Summary for 3LK8

Entry DOI	10.2210/pdb3lk8/pdb
Related	3F15 3F16 3F17 3F18 3F19 3F1A
Descriptor	Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	matrix metalloproteinase, metallo elastase, elastase inhibitor, glycoprotein, hydrolase, metal-binding, metalloprotease, protease
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : P39900
Total number of polymer chains	1
Total formula weight	17995.79
Authors	Calderone, V. (deposition date: 2010-01-27, release date: 2010-10-06, Last modification date: 2023-09-06)
Primary citation	Bertini, I.,Calderone, V.,Fragai, M.,Giachetti, A.,Loconte, M.,Luchinat, C.,Maletta, M.,Nativi, C.,Yeo, K.J. Exploring the subtleties of drug-receptor interactions: the case of matrix metalloproteinases J.Am.Chem.Soc., 129:2466-2475, 2007 Cited by PubMed: 17269766 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation