4GU3

Crystal structure of the T1L reovirus attachment protein sigma1 in complex with the GM2 glycan

Summary for 4GU3

Entry DOI	10.2210/pdb4gu3/pdb
Related	1KKE 3S6X 4GU4
Descriptor	Outer capsid protein sigma-1, N-acetyl-alpha-neuraminic acid-(2-3)-[2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose (2 entities in total)
Functional Keywords	triple beta-spiral, beta-barrel, beta-spiral repeat, greek key motif, viral attachment protein, gm2 glycan junctional adhesion molecule a, viral capsid, viral protein
Biological source	Mammalian orthoreovirus 1 (T1L)
Cellular location	Virion (By similarity): P04506
Total number of polymer chains	3
Total formula weight	76011.64
Authors	Reiss, K.,Stehle, T. (deposition date: 2012-08-29, release date: 2012-12-05, Last modification date: 2024-02-28)
Primary citation	Reiss, K.,Stencel, J.E.,Liu, Y.,Blaum, B.S.,Reiter, D.M.,Feizi, T.,Dermody, T.S.,Stehle, T. The GM2 Glycan Serves as a Functional Coreceptor for Serotype 1 Reovirus. Plos Pathog., 8:e1003078-e1003078, 2012 Cited by PubMed: 23236285 DOI: 10.1371/journal.ppat.1003078 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.6 Å)

Structure validation