4GMY

JAK2 kinase (JH1 domain) in complex with 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE

4GMY の概要

• エントリーDOI: 10.2210/pdb4gmy/pdb
• 関連するPDBエントリー: 4GFM 4GFO 4GIH
• 分子名称: Tyrosine-protein kinase JAK2, 2,6-dichloro-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide (3 entities in total)
• 機能のキーワード: jak2, jh1 kinase domain, tyrosine kinase, phosphotransferase, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endomembrane system; Peripheral membrane protein (By similarity): O60674
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35836.45

構造登録者

Murray, J.M.,Shia, S. (登録日: 2012-08-16, 公開日: 2013-06-19, 最終更新日: 2013-08-07)

• 主引用文献: Liang, J.,Tsui, V.,Van Abbema, A.,Bao, L.,Barrett, K.,Beresini, M.,Berezhkovskiy, L.,Blair, W.S.,Chang, C.,Driscoll, J.,Eigenbrot, C.,Ghilardi, N.,Gibbons, P.,Halladay, J.,Johnson, A.,Kohli, P.B.,Lai, Y.,Liimatta, M.,Mantik, P.,Menghrajani, K.,Murray, J.,Sambrone, A.,Xiao, Y.,Shia, S.,Shin, Y.,Smith, J.,Sohn, S.,Stanley, M.,Ultsch, M.,Zhang, B.,Wu, L.C.,Magnuson, S.; Lead identification of novel and selective TYK2 inhibitors.; Eur.J.Med.Chem., 67:175-187, 2013; PubMed: 23867602; DOI: 10.1016/j.ejmech.2013.03.070

実験手法

X-RAY DIFFRACTION (2.403 Å)