4GLR
Structure of the anti-ptau Fab (pT231/pS235_1) in complex with phosphoepitope pT231/pS235
Summary for 4GLR
Entry DOI | 10.2210/pdb4glr/pdb |
Related | 3BN9 3G6D 3GJE 3H42 3KYM 3MA9 |
Descriptor | phospho-peptide, anti-ptau heavy chain, anti-ptau light chain, ... (5 entities in total) |
Functional Keywords | igg1 fab, anti-ptau antibody, phosphorylated tau peptide, phosphorylation, immune system |
Biological source | Gallus gallus (chicken) More |
Total number of polymer chains | 6 |
Total formula weight | 95855.81 |
Authors | Tu, C.,Mosyak, L.,Bard, J. (deposition date: 2012-08-14, release date: 2012-11-21, Last modification date: 2023-09-13) |
Primary citation | Shih, H.H.,Tu, C.,Cao, W.,Klein, A.,Ramsey, R.,Fennell, B.J.,Lambert, M.,Ni Shuilleabhain, D.,Autin, B.,Kouranova, E.,Laxmanan, S.,Braithwaite, S.,Wu, L.,Ait-Zahra, M.,Milici, A.J.,Dumin, J.A.,Lavallie, E.R.,Arai, M.,Corcoran, C.,Paulsen, J.E.,Gill, D.,Cunningham, O.,Bard, J.,Mosyak, L.,Finlay, W.J. An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition. J.Biol.Chem., 287:44425-44434, 2012 Cited by PubMed: 23148212DOI: 10.1074/jbc.M112.415935 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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