4GLR

Structure of the anti-ptau Fab (pT231/pS235_1) in complex with phosphoepitope pT231/pS235

Summary for 4GLR

Related3GJE 3BN9 3KYM 3MA9 3G6D 3H42
Descriptorphospho-peptide, anti-ptau heavy chain, anti-ptau light chain, ... (5 entities in total)
Functional Keywordsigg1 fab, anti-ptau antibody, phosphorylated tau peptide, phosphorylation, immune system
Biological sourceGallus gallus (chicken)
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Total number of polymer chains6
Total molecular weight95855.81
Authors
Tu, C.,Mosyak, L.,Bard, J. (deposition date: 2012-08-14, release date: 2012-11-21, Last modification date: 2013-10-02)
Primary citation
Shih, H.H.,Tu, C.,Cao, W.,Klein, A.,Ramsey, R.,Fennell, B.J.,Lambert, M.,Ni Shuilleabhain, D.,Autin, B.,Kouranova, E.,Laxmanan, S.,Braithwaite, S.,Wu, L.,Ait-Zahra, M.,Milici, A.J.,Dumin, J.A.,Lavallie, E.R.,Arai, M.,Corcoran, C.,Paulsen, J.E.,Gill, D.,Cunningham, O.,Bard, J.,Mosyak, L.,Finlay, W.J.
An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition.
J.Biol.Chem., 287:44425-44434, 2012
PubMed: 23148212 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M112.415935
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.209201.0%2.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 4glr
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Molmil generated image of 4glr
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4glr.pdb1.gz [147.24 KB])
Coordinate files for Biological unit (4glr.pdb2.gz [145.27 KB])