4GLR
Structure of the anti-ptau Fab (pT231/pS235_1) in complex with phosphoepitope pT231/pS235
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 H 301 |
| Chain | Residue |
| H | PRO123 |
| H | LYS214 |
| H | SER215 |
| H | HOH588 |
| H | HOH594 |
| I | SER121 |
| I | SER122 |
| I | GLU123 |
| I | HOH435 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 K 301 |
| Chain | Residue |
| J | ALA125 |
| J | LYS214 |
| K | SER121 |
| K | SER122 |
| K | GLU123 |
| K | HOH421 |
| K | HOH509 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH |
| Chain | Residue | Details |
| I | TYR191-HIS197 | |
| H | TYR194-HIS200 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by GSK3-beta and PDPK1","evidences":[{"source":"PubMed","id":"14690523","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15546861","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16443603","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro","evidences":[{"source":"PubMed","id":"9326300","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
