4GLR
Structure of the anti-ptau Fab (pT231/pS235_1) in complex with phosphoepitope pT231/pS235
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 H 301 |
| Chain | Residue |
| H | PRO123 |
| H | LYS214 |
| H | SER215 |
| H | HOH588 |
| H | HOH594 |
| I | SER121 |
| I | SER122 |
| I | GLU123 |
| I | HOH435 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 K 301 |
| Chain | Residue |
| J | ALA125 |
| J | LYS214 |
| K | SER121 |
| K | SER122 |
| K | GLU123 |
| K | HOH421 |
| K | HOH509 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH |
| Chain | Residue | Details |
| I | TYR191-HIS197 | |
| H | TYR194-HIS200 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | SITE: Not glycated => ECO:0000269|PubMed:9326300 |
| Chain | Residue | Details |
| A | LYS224 | |
| A | LYS240 | |
| B | LYS224 | |
| B | LYS240 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| A | LYS225 | |
| B | LYS225 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by GSK3-beta and PDPK1 => ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | TPO231 | |
| B | TPO231 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PDPK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SEP235 | |
| B | SEP235 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:8999860 |
| Chain | Residue | Details |
| A | SER237 | |
| B | SER237 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro => ECO:0000269|PubMed:9326300 |
| Chain | Residue | Details |
| A | LYS225 | |
| A | LYS234 | |
| B | LYS225 | |
| B | LYS234 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:21327254 |
| Chain | Residue | Details |
| A | SER238 | |
| B | SER238 |
