4GL9

Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain

Summary for 4GL9

Entry DOI	10.2210/pdb4gl9/pdb
Descriptor	Tyrosine-protein kinase, Interleukin-6 receptor subunit beta, Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3, ... (5 entities in total)
Functional Keywords	kinase inhibitor receptor cytokine signalling, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	12
Total formula weight	210768.17
Authors	Kershaw, N.J.,Murphy, J.M.,Laktyushin, A.,Nicola, N.A.,Babon, J.J. (deposition date: 2012-08-14, release date: 2013-03-06, Last modification date: 2018-06-13)
Primary citation	Kershaw, N.J.,Murphy, J.M.,Liau, N.P.,Varghese, L.N.,Laktyushin, A.,Whitlock, E.L.,Lucet, I.S.,Nicola, N.A.,Babon, J.J. SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. Nat.Struct.Mol.Biol., 20:469-476, 2013 Cited by PubMed: 23454976 DOI: 10.1038/nsmb.2519 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.9 Å)

Structure validation