4GL9
Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain
Summary for 4GL9
Entry DOI | 10.2210/pdb4gl9/pdb |
Descriptor | Tyrosine-protein kinase, Interleukin-6 receptor subunit beta, Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3, ... (5 entities in total) |
Functional Keywords | kinase inhibitor receptor cytokine signalling, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 12 |
Total formula weight | 210768.17 |
Authors | Kershaw, N.J.,Murphy, J.M.,Laktyushin, A.,Nicola, N.A.,Babon, J.J. (deposition date: 2012-08-14, release date: 2013-03-06, Last modification date: 2018-06-13) |
Primary citation | Kershaw, N.J.,Murphy, J.M.,Liau, N.P.,Varghese, L.N.,Laktyushin, A.,Whitlock, E.L.,Lucet, I.S.,Nicola, N.A.,Babon, J.J. SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. Nat.Struct.Mol.Biol., 20:469-476, 2013 Cited by PubMed: 23454976DOI: 10.1038/nsmb.2519 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.9 Å) |
Structure validation
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