4GL9
Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain
4GL9 の概要
エントリーDOI | 10.2210/pdb4gl9/pdb |
分子名称 | Tyrosine-protein kinase, Interleukin-6 receptor subunit beta, Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3, ... (5 entities in total) |
機能のキーワード | kinase inhibitor receptor cytokine signalling, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Mus musculus (Mouse) 詳細 |
タンパク質・核酸の鎖数 | 12 |
化学式量合計 | 210768.17 |
構造登録者 | Kershaw, N.J.,Murphy, J.M.,Laktyushin, A.,Nicola, N.A.,Babon, J.J. (登録日: 2012-08-14, 公開日: 2013-03-06, 最終更新日: 2018-06-13) |
主引用文献 | Kershaw, N.J.,Murphy, J.M.,Liau, N.P.,Varghese, L.N.,Laktyushin, A.,Whitlock, E.L.,Lucet, I.S.,Nicola, N.A.,Babon, J.J. SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. Nat.Struct.Mol.Biol., 20:469-476, 2013 Cited by PubMed: 23454976DOI: 10.1038/nsmb.2519 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.9 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード