4GIH
Tyk2 (JH1) in complex with 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE
Summary for 4GIH
Entry DOI | 10.2210/pdb4gih/pdb |
Related | 4GFM 4GFO 4GII 4GJ2 4GJ3 4GMY 4GVJ |
Descriptor | Non-receptor tyrosine-protein kinase TYK2, 2,6-dichloro-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide (3 entities in total) |
Functional Keywords | tyrosine kinase, kinase, atp binding, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 35098.93 |
Authors | Ultsch, M.H. (deposition date: 2012-08-08, release date: 2013-06-19, Last modification date: 2023-09-13) |
Primary citation | Liang, J.,Tsui, V.,Van Abbema, A.,Bao, L.,Barrett, K.,Beresini, M.,Berezhkovskiy, L.,Blair, W.S.,Chang, C.,Driscoll, J.,Eigenbrot, C.,Ghilardi, N.,Gibbons, P.,Halladay, J.,Johnson, A.,Kohli, P.B.,Lai, Y.,Liimatta, M.,Mantik, P.,Menghrajani, K.,Murray, J.,Sambrone, A.,Xiao, Y.,Shia, S.,Shin, Y.,Smith, J.,Sohn, S.,Stanley, M.,Ultsch, M.,Zhang, B.,Wu, L.C.,Magnuson, S. Lead identification of novel and selective TYK2 inhibitors. Eur.J.Med.Chem., 67:175-187, 2013 Cited by PubMed: 23867602DOI: 10.1016/j.ejmech.2013.03.070 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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